Drug Interactions between resmetirom and Sudafed 12 Hour Pressure+Pain
This report displays the potential drug interactions for the following 2 drugs:
- resmetirom
- Sudafed 12 Hour Pressure+Pain (naproxen/pseudoephedrine)
Interactions between your drugs
naproxen resmetirom
Applies to: Sudafed 12 Hour Pressure+Pain (naproxen / pseudoephedrine) and resmetirom
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with resmetirom may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of the CYP450 2C8 isoenzyme. The proposed mechanism, based on in vitro and clinical data, is decreased clearance due to weak inhibition of CYP450 2C8 by resmetirom. In healthy study subjects, when a single dose of the CYP450 2C8 substrate pioglitazone (15 mg) was administered with resmetirom at steady state concentrations (100 mg daily), a 1.5-fold increase in pioglitazone systemic exposure (AUC) was observed. However, the peak plasma concentration (Cmax) of pioglitazone was unchanged.
MANAGEMENT: Caution and clinical monitoring is recommended if resmetirom is coadministered with drugs that are substrates of the CYP450 2C8 isoenzyme. Dosage adjustments as well as closer clinical and laboratory monitoring for the development of adverse effects may be appropriate for some drugs whenever resmetirom is added to or withdrawn from therapy. Individual product labeling should be consulted for further guidance.
References
- "Product Information. Rezdiffra (resmetirom)." Madrigal Pharmaceuticals, Inc. (2024):
Drug and food interactions
naproxen food
Applies to: Sudafed 12 Hour Pressure+Pain (naproxen / pseudoephedrine)
Ask your doctor before using naproxen together with ethanol. Do not drink alcohol while taking naproxen. Alcohol can increase your risk of stomach bleeding caused by naproxen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
pseudoephedrine food
Applies to: Sudafed 12 Hour Pressure+Pain (naproxen / pseudoephedrine)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.
MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.
References
- Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res 1 (1979): 45-52
- Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
- "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc PROD (2001):
- "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals PROD (2001):
- "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals PROD (2001):
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc (2001):
- "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company (2002):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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