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Drug Interactions between React and vorasidenib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

levonorgestrel vorasidenib

Applies to: React (levonorgestrel) and vorasidenib

Vorasidenib may reduce the blood levels and effects of levonorgestrel. If you are using hormonal contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy. Vorasidenib is likely associated with major birth defects, so it is particularly important that you do not become pregnant during treatment. Therefore, hormonal contraceptives should not be used as the sole method of birth control in women of childbearing potential treated with vorasidenib. You should discuss the use of alternative or additional non hormonal methods of birth control with your healthcare provider. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

levonorgestrel food

Applies to: React (levonorgestrel)

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Moderate

vorasidenib food

Applies to: vorasidenib

Smoking tobacco during treatment may decrease the blood levels and effectiveness of vorasidenib. Tell your doctor if you are a current or past tobacco smoker. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

levonorgestrel food

Applies to: React (levonorgestrel)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer