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Drug Interactions between Rapiblyk and vericiguat

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

landiolol vericiguat

Applies to: Rapiblyk (landiolol) and vericiguat

Consumer information for this interaction is not currently available.

MONITOR: Vericiguat may cause hypotension and coadministration with antihypertensives, organic nitrates, or agents with hypotensive properties may increase the potential for symptomatic hypotension, especially in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or patients with a history of hypotension. Patients with heart failure receiving hemodynamically active substances have reported systolic blood pressure (SBP) reductions of approximately 1 to 2 mmHg with concomitant use. Co-administration of multiple doses of vericiguat up to 10 mg once daily did not significantly alter the seated blood pressure effects of short- and long-acting nitrates in patients with coronary artery disease and concomitant use of short-acting nitrates was well tolerated in patients with heart failure. However, there is limited experience with concomitant use of vericiguat and long-acting nitrates in patients with heart failure and no data on initiation of vericiguat in patients with systolic blood pressure (SBP) less than 100 mmHg or symptomatic hypotension at treatment initiation.

MANAGEMENT: If patients experience tolerability issues (symptomatic hypotension or SBP less than 90 mmHg), temporary down-titration or discontinuation of vericiguat is recommended.

Drug and food interactions

Moderate

vericiguat food

Applies to: vericiguat

Food significantly enhances the absorption of vericiguat. You should take each dose of vericiguat at the same time each day with food. If you receive enteral nutrition (tube feeding), take vericiguat with your feeding. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking vericiguat with food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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