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Drug Interactions between Prepopik and sotorasib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

magnesium oxide sotorasib

Applies to: Prepopik (citric acid/magnesium oxide/sodium picosulfate) and sotorasib

By reducing the acidity level in the stomach, medications like magnesium oxide may interfere with the absorption of sotorasib into the bloodstream and reduce its effectiveness. It is generally best to avoid using these medications together when possible. However, if you have no other alternatives for treatment, it is recommended that you take sotorasib 4 hours before or 10 hours after magnesium oxide to help minimize the impact of the interaction. Some prescription and over-the-counter medications may also contain antacids or other agents that can neutralize acid. You should check the ingredients of all medications you take to see if they may contain antacids. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

sodium picosulfate food

Applies to: Prepopik (citric acid/magnesium oxide/sodium picosulfate)

Oral medications may not be properly absorbed when they are taken within one hour before starting sodium picosulfate for bowel cleansing. Talk to your doctor or pharmacist to see if you should adjust the dosing schedule of your other medications before you begin bowel cleansing treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

sotorasib food

Applies to: sotorasib

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer