Drug Interactions between Picot Plus and pitolisant

Using sodium bicarbonate together with aspirin may decrease the effects of aspirin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using pitolisant together with aspirin may increase the risk of side effects in the gastrointestinal tract such as upset stomach, bloating, abdominal pain or discomfort, and stomach inflammation. It is not known whether pitolisant will increase the risk of more serious gastrointestinal side effects such as bleeding and ulceration that are often associated with the use of aspirin and similar medications. You should take these medications with food to lessen the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Your doctor may also be able to recommend medications to help protect the stomach and intestine if you are at high risk for developing serious gastrointestinal complications. You should seek immediate medical attention if you experience severe gastrointestinal effects or have signs and symptoms of gastrointestinal bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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