Drug Interactions between paliperidone and valproic acid

Valproic acid may increase the blood levels of paliperidone (brand name Invega) when the medications are taken orally (as opposed to when given by injection). This may increase the risk of side effects such as drowsiness, Parkinson-like symptoms, abnormal muscle movements, high blood sugar, diabetes, cholesterol and lipid increases, weight gain, low white blood cell count, difficulty swallowing, and heat-related disorders such as heat intolerance or heat stroke. You may also be more likely to experience side effects associated with low blood pressure such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid driving or operating hazardous machinery until you know how these medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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