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Drug Interactions between paliperidone and papaverine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

papaverine paliperidone

Applies to: papaverine and paliperidone

Papaverine and paliperidone may have additive effects in lowering your blood pressure. Additionally, if papaverine is administered directly into your heart during a medical procedure, it may be associated with a rare, but potentially life-threatening, irregular heart rhythm. Paliperidone has also been associated with this rare adverse effect. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you. Your healthcare providers may be able to manage potential complications with additional monitoring. Contact your healthcare team if you have any additional questions. Seek immediate medical attention if you develop dizziness, lightheadedness, fainting, shortness of breath, and/or changes in pulse or heart rate. Avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying down position. It is important to let your doctor know about all other medications you use, including vitamins and herbs. Do not stop any medications without first talking to your doctor.

Drug and food interactions

Moderate

paliperidone food

Applies to: paliperidone

You should avoid the use of alcohol while being treated with paliperidone. Alcohol can increase the nervous system side effects of paliperidone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Paliperidone may be taken with or without food. Talk to your doctor or pharmacist if you have any questions or concerns.

Moderate

papaverine food

Applies to: papaverine

Papaverine and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer