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Drug Interactions between omeprazole and Prograf

This report displays the potential drug interactions for the following 2 drugs:

  • omeprazole
  • Prograf (tacrolimus)

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Interactions between your drugs

Major

omeprazole tacrolimus

Applies to: omeprazole and Prograf (tacrolimus)

Omeprazole may significantly increase the blood levels of tacrolimus in some patients. This may increase the risk of serious side effects such as diabetes, infections, kidney problems, hyperkalemia (high blood levels of potassium), tremor, seizures, visual disturbances, high blood pressure, and heart enlargement. In addition, chronic use of drugs known as proton pump inhibitors including omeprazole can sometimes cause hypomagnesemia (low blood levels of magnesium), and the risk may be further increased when combined with other medications that also have this effect such as tacrolimus. In severe cases, hypomagnesemia can lead to irregular heart rhythm, palpitations, muscle spasm, tremor, and seizures. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

tacrolimus food

Applies to: Prograf (tacrolimus)

Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.