Drug Interactions between olanzapine / samidorphan and oliceridine

Using samidorphan together with oliceridine is not recommended. Samidorphan can block the effects of opioids like oliceridine and make the medication less effective or ineffective in treating your condition. If you have been receiving opioid-containing medications for a while (for example, a week or longer), initiating samidorphan can also precipitate withdrawal symptoms that sometimes are severe enough to warrant hospitalization. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or direct you to stop using oliceridine for at least one to two weeks before you initiate treatment with samidorphan. Do not increase the dose or frequency of use of oliceridine on your own in order to overcome the opioid-blocking effects of samidorphan, as this may increase the risk of opioid overdose and death, especially when samidorphan is interrupted or discontinued. Following treatment with samidorphan, it takes some time for the opioid-blocking effect to go away and you may be more more sensitive to the effects of opioids during this time. If you have used opioid street drugs or opioid-containing medications in the past, using them in the amounts that you used before treatment with samidorphan can also lead to overdose and death. Therefore, you should wait at least 5 days after you stop treatment with samidorphan before you start using opioids. However, it is best to consult a healthcare provider before using any opioids. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using OLANZapine together with oliceridine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.