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Drug Interactions between Nylia 1 / 35 and olaparib

This report displays the potential drug interactions for the following 2 drugs:

  • Nylia 1/35 (ethinyl estradiol/norethindrone)
  • olaparib

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Interactions between your drugs

Moderate

ethinyl estradiol olaparib

Applies to: Nylia 1 / 35 (ethinyl estradiol / norethindrone) and olaparib

Olaparib may reduce the blood levels and effects of ethinyl estradiol. If you are using birth control pills or another hormone-type contraceptive such as a patch, shot, vaginal ring or implant, you should talk to your doctor before taking olaparib. You may need an alternative or additional method of birth control during treatment with olaparib in order to avoid an unintended pregnancy. Let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of ethinyl estradiol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

norethindrone olaparib

Applies to: Nylia 1 / 35 (ethinyl estradiol / norethindrone) and olaparib

Olaparib may reduce the blood levels and effects of norethindrone. If you are using birth control pills or another hormone-type contraceptive such as a patch, shot, vaginal ring or implant, you should talk to your doctor before taking olaparib. You may need an alternative or additional method of birth control during treatment with olaparib in order to avoid an unintended pregnancy. Let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of norethindrone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

olaparib food

Applies to: olaparib

Do not consume grapefruit, grapefruit juice, or Seville oranges during treatment with olaparib. Doing so can significantly increase the blood levels of olaparib and increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

norethindrone food

Applies to: Nylia 1 / 35 (ethinyl estradiol / norethindrone)

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Minor

ethinyl estradiol food

Applies to: Nylia 1 / 35 (ethinyl estradiol / norethindrone)

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.