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Drug Interactions between Noxafil and ombitasvir / paritaprevir / ritonavir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

posaconazole paritaprevir

Applies to: Noxafil (posaconazole) and ombitasvir / paritaprevir / ritonavir

Posaconazole may increase the blood levels of paritaprevir, one of the components of your hepatitis C medication. This may increase the risk and/or severity of side effects such as liver problems and excessive bilirubin levels in the blood, which in severe cases can lead to seizures and brain damage. However, in clinical trials, bilirubin elevations usually resolved with continued treatment. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

ritonavir food

Applies to: ombitasvir / paritaprevir / ritonavir

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

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Moderate

posaconazole food

Applies to: Noxafil (posaconazole)

Food significantly increases the absorption of posaconazole from the tablet or suspension formulations. The manufacturer recommends that you take the tablet with food and the oral suspension during or immediately (within 20 minutes) after a full meal. If you cannot eat a full meal, you should take the oral suspension with a liquid nutritional supplement like Ensure or an acidic carbonated beverage like ginger ale. Do not take these medications on an empty stomach, as it may lead to inadequate blood levels and reduced effectiveness. Ask your doctor before using alcohol together with posaconazole from delayed release suspension formulations as this may cause an increase in side effects. Talk to your doctor or pharmacist if you have any questions on how to use the medication properly.

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Moderate

paritaprevir food

Applies to: ombitasvir / paritaprevir / ritonavir

Food significantly increases the absorption of paritaprevir. You should take each dose of paritaprevir with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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