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Drug Interactions between norfloxacin and Tyblume

This report displays the potential drug interactions for the following 2 drugs:

  • norfloxacin
  • Tyblume (ethinyl estradiol/levonorgestrel)

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Interactions between your drugs


norfloxacin ethinyl estradiol

Applies to: norfloxacin and Tyblume (ethinyl estradiol / levonorgestrel)

Antibiotics such as norfloxacin may reduce the effects of ethinyl estradiol in some women. If you are using ethinyl estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. Talk to your healthcare provider to determine if you should use an alternative or additional form of birth control during treatment with norfloxacin. In addition, some birth control preparations may include "placebo" non-hormonal pills that contain iron. If you are taking these iron pills during treatment with norfloxacin, you should separate the dosing times by several hours so that the iron does not interfere with absorption of the antibiotic. Ask your doctor or pharmacist for information on when best to take these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


levonorgestrel food

Applies to: Tyblume (ethinyl estradiol / levonorgestrel)

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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norfloxacin food

Applies to: norfloxacin

Taking norfloxacin with food or products that contain minerals like calcium, iron, magnesium and zinc can interfere with its absorption and reduce its levels in the blood and urinary tract. This may make the medication less effective in treating your infection. You should take norfloxacin on an empty stomach at least one hour before or two hours after eating a meal or consuming milk or other dairy products. Do not use mineral supplements, multivitamins, antacids, or other products that may contain calcium, iron, magnesium or zinc within the two-hour period before or after taking norfloxacin. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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ethinyl estradiol food

Applies to: Tyblume (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.