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Drug Interactions between norethindrone and zolmitriptan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

norethindrone ZOLMitriptan

Applies to: norethindrone and zolmitriptan

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of hormonal contraceptives may increase plasma concentrations of zolmitriptan. A retrospective pharmacokinetic analysis indicates that mean peak plasma concentration (Cmax) and systemic exposure (AUC) of zolmitriptan were 30% and 50% higher, respectively, and time to peak plasma concentration (Tmax) was delayed by one-half hour in females taking oral contraceptives. The mechanism and clinical significance are unknown, although ethinyl estradiol-mediated inhibition of CYP450 1A2 may contribute, since zolmitriptan is a substrate of this isoenzyme. Products used for hormonal replacement therapy that contain estradiol or conjugated estrogens may also have a similar effect on zolmitriptan, although clinical data is not currently available. The effect of zolmitriptan on the pharmacokinetics of oral contraceptives has not been reported.

MANAGEMENT: Patients should be monitored for zolmitriptan-related adverse effects and notify their doctor promptly if they experience sedation, dizziness, paresthesia, chest pain or tightness, shortness of breath, or irregular heartbeats.

Drug and food interactions

Moderate

norethindrone food

Applies to: norethindrone

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Moderate

ZOLMitriptan food

Applies to: zolmitriptan

Alcohol can increase the nervous system side effects of ZOLMitriptan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with ZOLMitriptan. Do not use more than the recommended dose of ZOLMitriptan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Minor

norethindrone food

Applies to: norethindrone

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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