Drug Interactions between nitisinone and vadadustat
This report displays the potential drug interactions for the following 2 drugs:
- nitisinone
- vadadustat
Interactions between your drugs
nitisinone vadadustat
Applies to: nitisinone and vadadustat
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with moderate or potent inhibitors of the uptake transporters organic anion transporter 1 and/or 3 (OAT1, OAT3) may increase the plasma concentrations and the risk of adverse effects associated with vadadustat. According to the manufacturer, coadministration with probenecid, a potent OAT1/OAT3 inhibitor, increased systemic exposure (AUC) of vadadustat by almost 2-fold. Increased systemic exposure to vadadustat may result in a rapid rise in hemoglobin and increase the risk of adverse reactions such as thromboembolic events, diarrhea, hypertension, liver injury, seizures, pneumonia, and increased cardiovascular and mortality risk.
MANAGEMENT: Close clinical and laboratory monitoring for adverse effects is advised if vadadustat is used concomitantly with moderate or potent OAT1 and/or OAT3 inhibitors. Additionally, close monitoring of hemoglobin levels is advised following initiation or discontinuation of treatment with moderate or potent OAT1/OAT3 inhibitors, and the vadadustat dosage adjusted as necessary in accordance with the prescribing information.
Drug and food interactions
nitisinone food
Applies to: nitisinone
Grapefruit juice may increase the blood levels of certain medications such as nitisinone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with nitisinone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.
vadadustat food
Applies to: vadadustat
Consumer information for this interaction is not currently available.
MONITOR: Smoking and alcohol consumption during therapy with vadadustat may increase the risk of gastrointestinal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, have been reported during vadadustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.
MANAGEMENT: Caution is advised if vadadustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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