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Drug Interactions between Niphanoid and phenazopyridine / sulfamethoxazole

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sulfamethoxazole tetracaine

Applies to: phenazopyridine / sulfamethoxazole and Niphanoid (tetracaine)

Ask your doctor before using tetracaine together with sulfamethoxazole. Tetracaine may decrease the effects of sulfamethoxazole. Ask your doctor to consider an alternative to tetracaine. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phenazopyridine tetracaine

Applies to: phenazopyridine / sulfamethoxazole and Niphanoid (tetracaine)

Using phenazopyridine together with tetracaine may cause methemoglobinemia, a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood. Individuals may be more susceptible to developing methemoglobinemia during treatment with these medications if they are very young (especially neonates and infants) or have diseases of the heart or lungs, certain genetic predispositions, or glucose-6-phosphate dehydrogenase deficiency. Medical supervision may be necessary when medications that can cause methemoglobinemia are used together. Signs and symptoms of methemoglobinemia may occur immediately or hours after treatment. Patients or their caregivers should seek immediate medical attention if they develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

sulfamethoxazole food

Applies to: phenazopyridine / sulfamethoxazole

Ask your doctor before using sulfamethoxazole together with ethanol. Contact your doctor if you experience unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, or vomiting. If you experience these side effects, you may need to avoid ethanol while taking sulfamethoxazole. You should check your food and medicine labels to see if these products contain ethanol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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