Drug Interactions between nelfinavir and Viekira XR

Using nelfinavir together with ritonavir may increase the effects of nelfinavir. Contact your doctor if you experience increased urination or extreme thirst, easy bruising or bleeding, or signs of a new infection, such as fever or chills, cough, or flu symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Nelfinavir may increase the blood levels of paritaprevir, one of the components of your hepatitis C medication. This may increase the risk and/or severity of side effects such as liver problems and excessive bilirubin levels in the blood, which in severe cases can lead to seizures and brain damage. However, in clinical trials, bilirubin elevations usually resolved with continued treatment. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.