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Drug Interactions between naldemedine and RiVive

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

naloxone naldemedine

Applies to: RiVive (naloxone) and naldemedine

Using naloxone together with naldemedine may increase the risk of opioid withdrawal. Symptoms may include sweating, tearing, runny nose, chills, diarrhea, abdominal pain, nausea, vomiting, anxiety, insomnia, irritability, restlessness, and yawning. These medications should generally not be used together. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

naldemedine food

Applies to: naldemedine

Grapefruit juice can increase the blood levels of naldemedine. This may increase side effects and withdrawal symptoms such as sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning. You should limit the consumption of grapefruit and grapefruit juice during treatment with naldemedine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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