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Drug Interactions between MZM and phentermine / topiramate

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

methazolAMIDE topiramate

Applies to: MZM (methazolamide) and phentermine / topiramate

Talk to your doctor before using methazolAMIDE together with topiramate. Both of these medications can cause metabolic acidosis, a condition associated with elevated levels of acid in the blood, and combining them may increase the risk as well as severity of the condition. Patients with metabolic acidosis may have no symptoms at all, or they may experience tiredness, loss of appetite, irregular heartbeat, trouble thinking clearly, and rapid breathing. If left untreated, metabolic acidosis can also lead to kidney stones, brittle or soft bones (osteomalacia, osteopenia, osteoporosis), reduced growth rates in children, and harm to the unborn baby during pregnancy. Patients receiving these medications, whether together or alone, generally require a blood test to measure the level of acid in the blood before and during treatment. Another potential issue with combining these medications is the risk of heat-related disorders. Decreased sweating and increased body temperature have been reported, particularly in children. Heat stroke may occur during vigorous exercise or prolonged exposure to warm or hot weather. Increased fluid intake is recommended during treatment to help prevent heat-related problems and kidney stones. Contact your doctor immediately if you develop signs or symptoms of kidney stones such as sudden back pain, abdominal pain and blood in the urine, of if you have decreased sweating or a fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

phentermine topiramate

Applies to: phentermine / topiramate and phentermine / topiramate

Topiramate may increase the blood levels and effects of phentermine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects such as dizziness, restlessness, insomnia, tremor, headache, mood changes, palpitation, rapid heart beat, or blood pressure elevation. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

phentermine food

Applies to: phentermine / topiramate

Using phentermine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with phentermine. Do not use more than the recommended dose of phentermine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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