Drug Interactions between moxifloxacin / triamcinolone and Omnipaque 180 Redi-Unit

The injection of steroids together with radiocontrast dyes into the spine is not recommended, as it may increase the risk of seizures, meningitis, and inflammation of the spinal membranes. They may be given together by other routes.

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Moxifloxacin and other medications in its class can cause tendinitis and tendon rupture, and the risk may be increased when combined with a steroid such as triamcinolone. Older adults over 60 years of age and those who have received a kidney, heart, and/or lung transplant may be particularly susceptible. Tendon rupture can occur during or up to several months after finishing moxifloxacin treatment and may require surgery or result in prolonged disability. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Stop taking moxifloxacin and call your doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. You should also avoid exercise or use of the affected area until further instruction from your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Before you undergo any imaging procedure where iohexol may be injected directly into the spine, let your doctor know if you are currently being treated with moxifloxacin. Injection of iohexol into the spine can sometimes cause seizures, and the risk may be increased if you are also using other medications that can cause seizures such as moxifloxacin. You may be more susceptible if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may want to withhold moxifloxacin for a certain length of time before and after the procedure, or you may need to be monitored more closely during the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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