Drug Interactions between Monopril HCT and taurine

Although fosinopril and hydroCHLOROthiazide are frequently combined together, their effects may be additive on lowering your blood pressure. You may need a dose adjustment or special tests to safely take both medications. Contact your doctor if you have a reduced heart rate, dizziness, fainting, or headaches. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Consumer information for this interaction is not currently available.

MONITOR: Theoretically, concomitant use of taurine and antihypertensive agents or vasodilators may have additive blood pressure-lowering effects. The proposed mechanism has not been established but has been suggested, primarily through studies in animal models, that taurine has a homeostatic function on vascular smooth muscle and cardiac muscle. Several mechanisms by which taurine has been proposed to promote vasodilation include effects on the nitric oxide system, endothelial function, and inhibition of the renin-angiotensin-aldosterone and sympathetic systems. A 2018 meta-analysis reviewing the effects of orally administered taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans showed that, in the 7 studies that met the inclusion criteria, treatment with oral taurine led to a statistically significant improvement in SBP and DBP compared with placebo. The mean reduction in blood pressure was approximately 3 mmHg for both systolic and diastolic readings, with a range of 0 to 15 mmHg and 0 to 7 mmHg for SBP and DBP, respectively. The effects of taurine supplementation may also be more significant in those who are pre-hypertensive or hypertensive compared to those with normal or moderately low blood pressure, regardless of their health status. However, clinical data are limited.

MANAGEMENT: Caution and monitoring for hypotension are recommended if oral taurine supplements are used in combination with antihypertensives. Patients should be advised to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

Consumer information for this interaction is not currently available.

MONITOR: Theoretically, concomitant use of taurine and antihypertensive agents or vasodilators may have additive blood pressure-lowering effects. The proposed mechanism has not been established but has been suggested, primarily through studies in animal models, that taurine has a homeostatic function on vascular smooth muscle and cardiac muscle. Several mechanisms by which taurine has been proposed to promote vasodilation include effects on the nitric oxide system, endothelial function, and inhibition of the renin-angiotensin-aldosterone and sympathetic systems. A 2018 meta-analysis reviewing the effects of orally administered taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans showed that, in the 7 studies that met the inclusion criteria, treatment with oral taurine led to a statistically significant improvement in SBP and DBP compared with placebo. The mean reduction in blood pressure was approximately 3 mmHg for both systolic and diastolic readings, with a range of 0 to 15 mmHg and 0 to 7 mmHg for SBP and DBP, respectively. The effects of taurine supplementation may also be more significant in those who are pre-hypertensive or hypertensive compared to those with normal or moderately low blood pressure, regardless of their health status. However, clinical data are limited.

MANAGEMENT: Caution and monitoring for hypotension are recommended if oral taurine supplements are used in combination with antihypertensives. Patients should be advised to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.