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Drug Interactions between Metvixia and NegGram

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nalidixic acid methyl aminolevulinate topical

Applies to: NegGram (nalidixic acid) and Metvixia (methyl aminolevulinate topical)

Methyl aminolevulinate topical causes your skin to be more sensitive to light in areas where it has been applied. The risk and/or severity of reactions such as redness, scaling, swelling, stinging, and burning may be increased when it is used with other drugs that can also increase sensitivity to light such as nalidixic acid. You should avoid exposure to sunlight or bright indoor lights (examination lamps, operating room lamps, tanning beds, lights at close proximity) during and for 48 hours after treatment as directed by your doctor. Since sunscreens will not protect you against photosensitivity reactions associated with methyl aminolevulinate topical, you should protect treated areas by wearing a wide-brimmed hat or other protective apparel if exposure to sunlight or other intense lights cannot be avoided. Be advised to reduce your light exposure if you experience sensations of stinging and/or burning. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

nalidixic acid food

Applies to: NegGram (nalidixic acid)

Nalidixic acid and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of nalidixic acid into the bloodstream and reduce its effectiveness. If possible, it may be best to avoid taking multivitamin with minerals while your are being treated with nalidixic acid. Otherwise, you should take nalidixic acid either 2 hours before or 2 hours after the multivitamin with minerals dose. Talk to a healthcare professional if you are not sure whether a product contains something that could potentially interact with your medication or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

nalidixic acid food

Applies to: NegGram (nalidixic acid)

Using caffeine together with nalidixic acid may increase the effects of caffeine. Contact your doctor if you experience headache, tremor, restlessness, nervousness, insomnia, and increased blood pressure or heart rate. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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