Drug Interactions between methylprednisolone and pegaspargase

Using methylPREDNISolone together with pegaspargase may increase your blood sugar levels. Also, this combination may increase your risks of bone-tissue death (osteonecrosis), bleeding or blood clots. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if you have symptoms of high blood sugar such as increased thirst, increased hunger, and increased urination. Also, contact your doctor if you experience bone pain or any unusual bleeding or bruising; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds. Also be alert to potential signs and symptoms of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity, and seek immediate medical attention if they occur. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.