Drug Interactions between Methylphen and safinamide
This report displays the potential drug interactions for the following 2 drugs:
- Methylphen (benzoic acid/hyoscyamine/methenamine/methylene blue/phenyl salicylate)
- safinamide
Interactions between your drugs
methylene blue safinamide
Applies to: Methylphen (benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate) and safinamide
Using methylene blue together with safinamide is not recommended. Combining these medications may increase the risk of a hypertensive crisis, which is a life-threatening side effect associated with dangerously high blood pressure caused by consuming certain foods or beverages that are high in tyramine content (e.G., air dried, aged, or fermented meats; sausage or salami; pickled herring; anchovies; liver; red wine; beer; aged cheeses; sour cream; sauerkraut; canned figs; raisins; overly ripened bananas or avocados; soy beans; soy sauce; tofu; bean curds; fava beans; yeast extracts). In addition, you may have an increased risk of developing a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should wait at least 14 days after stopping one medication before starting treatment with the other. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
safinamide food
Applies to: safinamide
While you are taking safinamide, you must not eat or drink certain foods and beverages that are high in tyramine. Eating these foods while you are taking safinamide can raise your blood pressure to dangerous levels. This may cause life threatening symptoms such as sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body). Call your doctor at once if you have any of these symptoms. Foods that are high in tyramine include: air dried meats, aged or fermented meats, sausage or salami, pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver, red wine, beer from a tap, beer that has not been pasteurize, aged cheeses, including blue, brick, brie, cheddar, parmesan, romano, and swiss, sauerkraut, over the counter supplements or cough and cold medicines that contain tyramine, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans, or yeast extracts (such as Marmite). Talk to your doctor or pharmacist if you are uncertain about what foods, if any, to avoid. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
hyoscyamine food
Applies to: Methylphen (benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate)
Ask your doctor before using hyoscyamine together with ethanol. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking hyoscyamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.