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Drug Interactions between methylnaltrexone and olanzapine / samidorphan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

methylnaltrexone samidorphan

Applies to: methylnaltrexone and olanzapine / samidorphan

Using methylnaltrexone together with samidorphan may increase the risk of opioid withdrawal. Symptoms may include sweating, tearing, runny nose, chills, diarrhea, abdominal pain, nausea, vomiting, anxiety, insomnia, irritability, restlessness, and yawning. These medications should generally not be used together. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

OLANZapine food

Applies to: olanzapine / samidorphan

Alcohol can increase the nervous system side effects of OLANZapine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with OLANZapine. Do not use more than the recommended dose of OLANZapine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Moderate

methylnaltrexone food

Applies to: methylnaltrexone

Food may reduce the absorption of methylnaltrexone when taken orally, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take oral preparations of methylnaltrexone on an empty stomach at least 30 minutes before your first meal of the day.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer