Drug Interactions between Methadone Diskets and pramlintide

Do not use alcohol or medications that contain alcohol while you are receiving treatment with methadone. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. You should also avoid consuming grapefruit and grapefruit juice, as this may increase the blood levels and effects of oral methadone. High blood levels of methadone can also occasionally cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. Do not exceed the dose of methadone prescribed for you or use the medication more frequently or for a longer duration than prescribed by your doctor. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

Pramlintide may interact with other medications if taken at the same time. Your other medications should be administered at least 1 hour before or 2 hours after your pramlintide injection. Talk with your doctor before using alcohol while you are using pramlintide. Using pramlintide together with alcohol can lead to hypoglycemia (low blood sugar). Alcohol can cause increased blood sugar due to the calories in alcoholic beverages. You may need a dose adjustment and you may need to check your blood sugar more often.