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Drug Interactions between mavacamten and Rapiblyk

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

landiolol mavacamten

Applies to: Rapiblyk (landiolol) and mavacamten

Consumer information for this interaction is not currently available.

MONITOR CLOSELY: Concomitant use of other drugs that reduce cardiac contractility may potentiate the negative inotropic effects of mavacamten and increase the risk of heart failure.

MANAGEMENT: Close medical supervision and monitoring of left ventricular ejection fraction (LVEF) are recommended if a negative inotrope is initiated or the dose increased during treatment with mavacamten. The prescribing information suggests that use of mavacamten in patients on beta blocker therapy and either diltiazem or verapamil should be avoided. New or worsening arrhythmia, dyspnea, chest pain, fatigue, palpitations, leg edema, or elevations in N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be signs and symptoms of heart failure and should also prompt an echocardiographic evaluation of cardiac function. Asymptomatic LVEF reduction, intercurrent illnesses (e.g., serious infections), and arrhythmias (e.g., atrial fibrillation or other uncontrolled tachyarrhythmia) require additional dosing considerations.

Drug and food interactions

Major

mavacamten food

Applies to: mavacamten

Grapefruit juice may increase the blood levels of mavacamten and increase the risk of heart failure, a condition where the heart is unable to pump blood adequately to meet the body's needs. Your risk may be further increased if you develop a serious infection or irregular heartbeat during treatment with mavacamten. You should avoid the consumption of grapefruit and grapefruit juice while taking this medication. Talk to your doctor if you have any questions or concerns. You should seek medical attention if you experience signs and symptoms of heart failure such as shortness of breath, chest pain, fatigue, swelling in your legs, palpitations, or rapid weight gain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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