Drug Interactions between lumateperone and zuranolone
This report displays the potential drug interactions for the following 2 drugs:
- lumateperone
- zuranolone
Interactions between your drugs
lumateperone zuranolone
Applies to: lumateperone and zuranolone
Zuranolone may cause sedation, dizziness, confusion, and trouble walking. The risk and/or severity may be increased when combined with other antidepressants or other medications that can also cause sedation. Let your doctor know prior to receiving zuranolone if you are currently using alcohol or receiving treatment with lumateperone, as you may be more likely to experience sedation-related side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Do not drive, operate machinery, or engage in potentially hazardous activities requiring mental alertness and motor coordination until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
lumateperone food
Applies to: lumateperone
Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this may increase the risk of side effects such as drowsiness, abnormal muscle movements, seizures, high blood sugar, diabetes, high cholesterol, weight gain, low white blood cell count, difficulty swallowing, and heat-related disorders such as heat intolerance or heat stroke. You may also be more likely to experience side effects associated with low blood pressure such as dizziness. You should avoid the consumption of grapefruit and grapefruit juice during treatment with lumateperone. Be sure to take the medication with food. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
zuranolone food
Applies to: zuranolone
Zuranolone must be taken with fat-containing food to ensure adequate absorption of the mediation. It is also best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of zuranolone. You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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