Can you take Lumakras with Relacorilant?
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- Lumakras (sotorasib)
- relacorilant
Drug interactions
Moderate drug interactions
Moderate:
sotorasib relacorilant
Applies to: Lumakras (sotorasib) and relacorilant
Sotorasib may reduce the blood levels of relacorilant, which may make the medication less effective in treating your condition.
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
relacorilant Food/Lifestyle
Applies to: relacorilant
Food helps to increase the absorption of relacorilant.
To ensure adequate blood levels, relacorilant should be given with food.
Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Minor food/lifestyle interactions
Minor:
sotorasib Food/Lifestyle
Applies to: Lumakras (sotorasib)
Food does not appear to have a clinically significant effect on the oral bioavailability of sotorasib. When a 960 mg dose of sotorasib was administered to study patients with a high-fat, high-calorie meal (approximately 800 to 1000 calories; 150, 250, and 500 to 600 calories from protein, carbohydrate, and fat, respectively), sotorasib peak plasma concentration (Cmax) did not change while systemic exposure (AUC 0-24 hours) increased by 25% compared to administration under fasted conditions. Sotorasib can be administered with or without food at approximately the same time each day.
The information above is from our professional interaction data. Consumer information is not available for this interaction.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Liver Disease and Renal Dysfunction.
Liver Disease
Moderate:
Lumakras
The sotorasib in Lumakras has a moderate potential interaction with Liver Disease.
The effects of severe renal impairment or moderate to severe hepatic impairment on the pharmacokinetics of sotorasib have not been studied.
Renal Dysfunction
Moderate:
Lumakras
The sotorasib in Lumakras has a moderate potential interaction with Renal Dysfunction.
The effects of severe renal impairment or moderate to severe hepatic impairment on the pharmacokinetics of sotorasib have not been studied.
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Lumakras
A total of 537 drugs are known to interact with Lumakras.
- Lumakras is in the drug class miscellaneous antineoplastics.
- Lumakras is used to treat the following conditions:
relacorilant
A total of 493 drugs are known to interact with relacorilant.
- Relacorilant is in the drug class miscellaneous antineoplastics.
- Relacorilant is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.