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Drug Interactions between lorcaserin and lurasidone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

lurasidone lorcaserin

Applies to: lurasidone and lorcaserin

Using lorcaserin together with lurasidone may increase the risk of a rare but serious condition called the neuroleptic malignant syndrome, which may include symptoms such as agitation, confusion, delusion, hallucination, extreme changes in blood pressure, excessive sweating, fever, shivering or shaking, restlessness, muscle spasm or stiffness, tremor, and incoordination. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. In addition, both lorcaserin and lurasidone, especially when given long-term, can cause increases in the levels of a hormone called prolactin. The health effects of high levels of prolactin are not known; however, some patients (including men) have experienced increased breast size and milk or milky discharge from the breasts. Some breast cancers may also be dependent on prolactin; therefore, let your doctor know if you have a history of breast cancer. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

lurasidone food

Applies to: lurasidone

Avoid consuming grapefruit or grapefruit juice during treatment with lurasidone, as it may increase blood levels of the medication. This can increase the risk of side effects such as Parkinson-like symptoms, abnormal muscle movements, seizures, high blood sugar, diabetes, high cholesterol, weight gain, sex hormone irregularities, and heat-related disorders such as heat intolerance or heat stroke. In addition, you may be more likely to experience side effects associated with low blood pressure such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. You should also avoid the use of alcohol while being treated with lurasidone. Alcohol can increase the nervous system and blood-pressure lowering effects of lurasidone. You may experience increased drowsiness, dizziness, difficulty concentrating, and impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns. Lurasidone should be taken with food consisting of at least 350 calories. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position.

Minor

lorcaserin food

Applies to: lorcaserin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer