Drug Interactions between lopinavir / ritonavir and omaveloxolone

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

Food may affect the absorption of lopinavir-ritonavir (brand name Kaletra) depending on whether you are taking the oral solution or the tablet. The oral solution should be taken with food to enhance absorption and help it work better. The tablet formulation can be take with or without food. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Omaveloxolone should be taken on an empty stomach, at least one hour before eating. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with omaveloxolone unless directed otherwise by your doctor. Grapefruit juice may increase the blood levels of omaveloxolone. This may increase the risk of side effects such as changes in the amount of cholesterol in the blood and changes in liver and heart function tests. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.