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Drug Interactions between lofexidine and Rapiblyk

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

lofexidine landiolol

Applies to: lofexidine and Rapiblyk (landiolol)

Consumer information for this interaction is not currently available.

GENERALLY AVOID: The hypotensive and bradycardic effects of lofexidine may be increased if it is used concurrently with other medications capable of these effects. Clinical trials reported orthostatic hypotension (29% and 42%), bradycardia (24% and 32%), and hypotension (30% and 30%) more frequently in patients on lofexidine 2.16 mg and 2.88 mg, respectively, compared to placebo (5%, 5%, and 1%, respectively).

MANAGEMENT: Concomitant use of lofexidine with medications that can decrease pulse rate or blood pressure should generally be avoided. If patients are using lofexidine in an outpatient setting, they should be capable of and counseled on self-monitoring for hypotension, orthostasis, and bradycardia. Patients should also be instructed to remain hydrated, rise carefully from a sitting or lying down position, and to contact their healthcare provider for guidance on dosing if hypotension or bradycardia occur.

Drug and food interactions

Moderate

lofexidine food

Applies to: lofexidine

Alcohol can increase the nervous system side effects of lofexidine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with lofexidine. Do not use more than the recommended dose of lofexidine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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