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Drug Interactions between Livdelzi and sonidegib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sonidegib seladelpar

Applies to: sonidegib and Livdelzi (seladelpar)

Sonidegib may increase the blood levels of seladelpar. This can increase the risk and/or severity of side effects such as changes in your liver tests, headache, stomach pain or swelling (distension), nausea, and/or dizziness. Your healthcare provider may already be aware of the risks, but has determined that this is the best course of treatment for you and is monitoring you closely for any potential complications. Speak with your healthcare provider right away if you develop any of the following signs or symptoms during treatment with seladelpar as they may indicate worsening liver problems: swelling of your stomach-area (abdomen) from a build-up of fluid, yellowing of your skin or the whites of your eyes, pain on the right side of your stomach, coughing or vomiting up blood or blood clots, red or black stools that look like tar, and/or mental changes like confusion, slurred speech, or changes in personality. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

sonidegib food

Applies to: sonidegib

Sonidegib should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal. The presence of food can significantly increase the absorption of sonidegib into the blood stream. This may increase side effects such as muscle spasms, muscle pain, muscle weakness, fatigue, nausea, vomiting, diarrhea, loss of appetite, weight loss, hair loss, itching, and taste abnormalities. You may also have an increased risk of developing a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with sonidegib, especially if these symptoms are accompanied by fever or dark colored urine. Grapefruit juice may also increase the blood levels of sonidegib and should be avoided. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer