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Drug Interactions between Limbitrol DS and posaconazole

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

amitriptyline posaconazole

Applies to: Limbitrol DS (amitriptyline / chlordiazepoxide) and posaconazole

Consumer information for this interaction is not currently available.

CONTRAINDICATED: Coadministration with posaconazole may increase the plasma concentrations of CYP450 3A4 substrates that can prolong the QT interval, possibly resulting in QT prolongation and cases of torsade de pointes (TdP). The underlying mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by posaconazole. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).

MANAGEMENT: Coadministration of posaconazole with CYP450 3A4 substrates that can prolong the QT interval is considered contraindicated.

References

  1. "Product Information. Noxafil (posaconazole)." Schering-Plough Corporation (2006):
  2. Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
  3. "Product Information. Posaconazole (AKM) (posaconazole)." Pharmacor Pty Ltd (2022):
  4. "Product Information. Posaconazole (posaconazole)." Morningside Healthcare Ltd (2024):
  5. "Product Information. Posaconazole (posaconazole)." Eugia US LLC (2023):
  6. "Product Information. Gln-Posaconazole (posaconazole)." Glenmark Pharmaceuticals Canada Inc (2023):
View all 6 references
Moderate

amitriptyline chlordiazePOXIDE

Applies to: Limbitrol DS (amitriptyline / chlordiazepoxide) and Limbitrol DS (amitriptyline / chlordiazepoxide)

Using amitriptyline together with chlordiazePOXIDE may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

chlordiazePOXIDE food

Applies to: Limbitrol DS (amitriptyline / chlordiazepoxide)

Alcohol can increase the nervous system side effects of chlordiazePOXIDE such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlordiazePOXIDE. Do not use more than the recommended dose of chlordiazePOXIDE, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate

posaconazole food

Applies to: posaconazole

Food significantly increases the absorption of posaconazole from the tablet or suspension formulations. The manufacturer recommends that you take the tablet with food and the oral suspension during or immediately (within 20 minutes) after a full meal. If you cannot eat a full meal, you should take the oral suspension with a liquid nutritional supplement like Ensure or an acidic carbonated beverage like ginger ale. Do not take these medications on an empty stomach, as it may lead to inadequate blood levels and reduced effectiveness. Ask your doctor before using alcohol together with posaconazole from delayed release suspension formulations as this may cause an increase in side effects. Talk to your doctor or pharmacist if you have any questions on how to use the medication properly.

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Moderate

amitriptyline food

Applies to: Limbitrol DS (amitriptyline / chlordiazepoxide)

Ask your doctor before using amitriptyline together with ethanol, this can alter the effects of amitriptyline and cause increased side effects. Call the doctor if you experience uneven heartbeats, extreme drowsiness, confusion, agitation, vomiting, blurred vision, sweating, muscle stiffness, feeling light-headed, and seizures. You should be warned not to exceed recommended dosages, to avoid alcohol, and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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