Can you take Levothyroxine / liothyronine with Multifol Plus?
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- levothyroxine/liothyronine
- Multifol Plus (multivitamin, prenatal)
Drug interactions
Moderate drug interactions
Moderate:
liotrix multivitamins, prenatal
Applies to: levothyroxine / liothyronine and Multifol Plus (multivitamin, prenatal)
Using multivitamins, prenatal together with liotrix may decrease the effects of liotrix. You should separate the administration of liotrix and multivitamins, prenatal by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
liotrix Food/Lifestyle
Applies to: levothyroxine / liothyronine
The timing of meals relative to your oral liotrix dose can affect the absorption of the medication. Therefore, liotrix should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of liotrix may be decreased and/or delayed by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, calcium, calcium fortified juices and grapefruit or grapefruit juice. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
multivitamins, prenatal Food/Lifestyle
Applies to: Multifol Plus (multivitamin, prenatal)
Food may reduce the absorption and blood levels of multivitamins, prenatal. In addition, some oral medications can also interfere with multivitamins, prenatal absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, multivitamins, prenatal may interfere with the absorption of other orally administered medications. You should take multivitamins, prenatal on an empty stomach at least one hour before or two hours after a meal. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
liotrix multivitamins with minerals
Applies to: levothyroxine / liothyronine
Using multivitamins with minerals together with liotrix may decrease the effects of liotrix. You should separate the administration of liotrix and multivitamins with minerals by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
7 potential interactions Applies to: 7 conditions, including High Blood Pressure, Seizures, Hyperthyroidism, Heart Disease, and Diabetes Insipidus.
Adrenal Insufficiency
Major:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a major potential interaction with Adrenal Insufficiency.
The use of thyroid hormones is contraindicated in patients with uncorrected adrenal insufficiency. Thyroid hormones increase tissue demand for adrenocortical hormones and may precipitate acute adrenal crisis. In patients with controlled adrenal insufficiency or other endocrine disorders, therapy for these concomitant disorders may need to be adjusted following thyroid replacement, since hypothyroidism often obscure or diminish the signs and symptoms of these conditions. Clinical monitoring of thyroid and adrenal function as well as any other appropriate endocrine function is recommended during thyroid hormone therapy.
Diabetes Insipidus
Moderate:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a moderate potential interaction with Diabetes Insipidus.
Since hypothyroidism often obscure or diminish the signs and symptoms of endocrine disorders such as diabetes mellitus or diabetes insipidus, thyroid replacement therapy may aggravate the intensity of symptoms associated with these conditions. Patients with endocrine disorders should be monitored more closely during thyroid hormone therapy, and their medication regimen adjusted accordingly. If thyroid medication is later discontinued, a downward readjustment of insulin or oral hypoglycemic agent may be necessary in patients with diabetes mellitus to avoid hypoglycemia.
Diabetes Mellitus
Moderate:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a moderate potential interaction with Diabetes Mellitus.
Since hypothyroidism often obscure or diminish the signs and symptoms of endocrine disorders such as diabetes mellitus or diabetes insipidus, thyroid replacement therapy may aggravate the intensity of symptoms associated with these conditions. Patients with endocrine disorders should be monitored more closely during thyroid hormone therapy, and their medication regimen adjusted accordingly. If thyroid medication is later discontinued, a downward readjustment of insulin or oral hypoglycemic agent may be necessary in patients with diabetes mellitus to avoid hypoglycemia.
Heart Disease
Major:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a major potential interaction with Heart Disease.
Thyroid hormones cause increases in myocardial contractility and heart rate as a result of increased metabolic demands and oxygen consumption. Therapy with thyroid hormones should be administered cautiously and initiated at reduced dosages in patients with cardiovascular disorders such as angina, coronary artery disease, and hypertension. Clinical monitoring of cardiovascular function is recommended. If chest pain or exacerbation of cardiovascular disease occurs, the dosage of thyroid hormone should be reduced, even at the expense of achieving euthyroid state. Thyroid hormones should not be administered to patients with an acute myocardial infarction that is not complicated by hypothyroidism.
High Blood Pressure
Major:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a major potential interaction with High Blood Pressure.
Thyroid hormones cause increases in myocardial contractility and heart rate as a result of increased metabolic demands and oxygen consumption. Therapy with thyroid hormones should be administered cautiously and initiated at reduced dosages in patients with cardiovascular disorders such as angina, coronary artery disease, and hypertension. Clinical monitoring of cardiovascular function is recommended. If chest pain or exacerbation of cardiovascular disease occurs, the dosage of thyroid hormone should be reduced, even at the expense of achieving euthyroid state. Thyroid hormones should not be administered to patients with an acute myocardial infarction that is not complicated by hypothyroidism.
Hyperthyroidism
Major:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a major potential interaction with Hyperthyroidism.
The use of thyroid hormones is contraindicated in patients with untreated thyrotoxicosis of any etiology, since thyroid hormones may exacerbate the condition.
Seizures
Moderate:
levothyroxine / liothyronine
The liotrix in levothyroxine / liothyronine has a moderate potential interaction with Seizures.
Thyroid hormones may alter the seizure threshold. Seizures have been reported rarely following the initiation of levothyroxine therapy. Therapy with thyroid hormones should be administered cautiously in patients predisposed to seizures.
Report options
More resources
levothyroxine / liothyronine
A total of 222 drugs are known to interact with levothyroxine / liothyronine.
- Levothyroxine / liothyronine is in the drug class thyroid drugs.
- Levothyroxine / liothyronine is used to treat Underactive Thyroid.
Multifol Plus
A total of 172 drugs are known to interact with Multifol Plus.
- Multifol plus is in the following drug classes: iron products, vitamin and mineral combinations.
- Multifol plus is used to treat Vitamin/Mineral Supplementation during Pregnancy/Lactation.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.