Drug Interactions between letibotulinumtoxinA and Norpace
This report displays the potential drug interactions for the following 2 drugs:
- letibotulinumtoxinA
- Norpace (disopyramide)
Interactions between your drugs
disopyramide letibotulinumtoxinA
Applies to: Norpace (disopyramide) and letibotulinumtoxinA
Consumer information for this interaction is not currently available.
MONITOR: Use of anticholinergic drugs after administration of botulinum toxin may potentiate systemic anticholinergic effects such as dry mouth, blurred vision, and urinary disorders. Botulinum toxin inhibits the release of acetylcholine from peripheral cholinergic nerve endings, thus additive or synergistic anticholinergic effects may occur when these agents are used together.
MANAGEMENT: Patients should be advised that systemic anticholinergic side effects such as dry mouth, blurred vision, and urinary disorders may increase if agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) are used after administration of botulinum toxin.
References
- "Product Information. Myobloc (rimabotulinumtoxinB)." Elan Pharmaceuticals PROD
- "Product Information. Dysport (abobotulinumtoxinA)." Tercica Inc PROD
- "Product Information. Botox (onabotulinumtoxinA)." Allergan Inc PROD
- "Product Information. Xeomin (incobotulinumtoxinA)." Merz Pharmaceuticals (2022):
- "Product Information. Jeuveau (prabotulinumtoxinA)." Evolus, Inc. (2022):
- "Product Information. Daxxify (daxibotulinumtoxinA)." Revance Therapeutics, Inc. 1 (2022):
- "Product Information. Letybo (letibotulinumtoxinA)." CROMA Australia Pty Ltd 1 (2022):
- "Product Information. Letybo (letibotulinumtoxinA)." Hugel Aesthetics (2024):
Drug and food interactions
disopyramide food
Applies to: Norpace (disopyramide)
Grapefruit juice may increase the blood levels of certain medications such as disopyramide. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with disopyramide. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.
disopyramide food
Applies to: Norpace (disopyramide)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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