Drug Interactions between leniolisib and nilotinib
This report displays the potential drug interactions for the following 2 drugs:
- leniolisib
- nilotinib
Interactions between your drugs
nilotinib leniolisib
Applies to: nilotinib and leniolisib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with drugs that are moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of leniolisib, which is primarily metabolized by the isoenzyme. Physiological-based pharmacokinetic (PBPK) modeling predicts that concomitant use with the moderate CYP450 3A4 inhibitor, erythromycin, may lead to an increase in systemic exposure (AUC 0-12h) of leniolisib by 75%. Increased exposure to leniolisib may increase the risk of adverse effects such as headache, sinusitis, and atopic dermatitis. Clinical data are not available.
MANAGEMENT: Caution and monitoring are advisable, particularly following initiation, discontinuation, or change of dosage of the moderate CYP450 3A4 inhibitor in people stabilized on their leniolisib therapy. Some authorities recommend to avoid concomitant use of moderate CYP450 3A4 inhibitors and leniolisib (UK).
Drug and food interactions
nilotinib food
Applies to: nilotinib
Do not consume grapefruit or grapefruit juice during treatment with nilotinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of nilotinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with nilotinib. Food may also increase the blood levels of nilotinib. Therefore, you should take nilotinib on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking nilotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
leniolisib food
Applies to: leniolisib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inhibitors of CYP450 3A4 including grapefruit or grapefruit juice may increase the plasma concentrations of leniolisib, which undergoes extensive CYP450 3A4-mediated first-pass metabolism in the gut wall and liver. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of leniolisib. Some authorities recommend to avoid grapefruit products during leniolisib treatment (UK).
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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