Drug Interactions between leniolisib and mavacamten
This report displays the potential drug interactions for the following 2 drugs:
- leniolisib
- mavacamten
Interactions between your drugs
mavacamten leniolisib
Applies to: mavacamten and leniolisib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of leniolisib. The proposed mechanism is accelerated clearance of leniolisib due to induction of the CYP450 3A4 isoenzyme, which is the primary route of elimination of leniolisib. Pharmacokinetic-based physiologic modeling predicts that concomitant use of leniolisib with the potent CYP450 3A4 rifampin or moderate CYP450 3A4 inducer efavirenz may decrease the systemic exposure (AUC 0-12h) of leniolisib by 78% and 58%, respectively. The extent to which other, less potent CYP450 3A4 inducers may interact with leniolisib is unknown.
MANAGEMENT: The potential for diminished pharmacologic effects of leniolisib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected. Patients should be advised to notify their physician if their symptoms worsen or their condition changes.
Drug and food interactions
mavacamten food
Applies to: mavacamten
Grapefruit juice may increase the blood levels of mavacamten and increase the risk of heart failure, a condition where the heart is unable to pump blood adequately to meet the body's needs. Your risk may be further increased if you develop a serious infection or irregular heartbeat during treatment with mavacamten. You should avoid the consumption of grapefruit and grapefruit juice while taking this medication. Talk to your doctor if you have any questions or concerns. You should seek medical attention if you experience signs and symptoms of heart failure such as shortness of breath, chest pain, fatigue, swelling in your legs, palpitations, or rapid weight gain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
leniolisib food
Applies to: leniolisib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inhibitors of CYP450 3A4 including grapefruit or grapefruit juice may increase the plasma concentrations of leniolisib, which undergoes extensive CYP450 3A4-mediated first-pass metabolism in the gut wall and liver. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of leniolisib. Some authorities recommend to avoid grapefruit products during leniolisib treatment (UK).
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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