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Drug Interactions between Kimyrsa and telaprevir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

telaprevir oritavancin

Applies to: telaprevir and Kimyrsa (oritavancin)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, which are metabolized by the isoenzyme. In 16 study subjects, administration of a single 750 mg dose of telaprevir during treatment with the potent CYP450 3A4 inducer rifampin (600 mg daily for 7 days) reduced the telaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 86% and 92%, respectively, compared to administration alone. No data are available for boceprevir; however, a similar interaction is expected.

MANAGEMENT: Caution is recommended if boceprevir or telaprevir is used in combination with a CYP450 3A4 inducer. Close clinical monitoring of the virologic response to the HCV NS3/4A protease inhibitor is recommended.

Drug and food interactions

Moderate

telaprevir food

Applies to: telaprevir

Food significantly increases the absorption of telaprevir. Within 30 minutes before you take each dose of telaprevir, you should eat a meal or snack containing approximately 20 grams of fat. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Examples of some foods that could be taken with telaprevir include: bagel with cream cheese; half cup of nuts; 3 tablespoons of peanut butter; 1 cup of ice cream; 2 ounces of American or cheddar cheese; 2 ounces of potato chips; or half cup of trail mix. Talk to your healthcare provider if you have additional questions about how to take telaprevir.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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