Drug Interactions between ixabepilone and rufinamide
This report displays the potential drug interactions for the following 2 drugs:
- ixabepilone
- rufinamide
Interactions between your drugs
ixabepilone rufinamide
Applies to: ixabepilone and rufinamide
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ixabepilone, which is primarily metabolized by the isoenzyme. According to the manufacturer, coadministration of ixabepilone with the potent CYP450 3A4 inducer rifampin decreased ixabepilone systemic exposure (AUC) by 43% compared to administration of ixabepilone alone. Reduced efficacy of ixabepilone may occur. However, the extent to which less potent CYP450 3A4 inducers interact with ixabepilone is unknown.
MANAGEMENT: The potential for diminished pharmacologic effects of ixabepilone should be considered during coadministration with CYP450 3A4 inducers. Caution is advised if they are used with ixabepilone, and alternative treatments may be required if an interaction is suspected.
References
- "Product Information. Ixempra (ixabepilone)." R-Pharm US LLC (2023):
Drug and food interactions
ixabepilone food
Applies to: ixabepilone
Do not consume grapefruit or grapefruit juice during treatment with ixabepilone unless specifically directed otherwise by your doctor. Ixabepilone can interact with grapefruit and grapefruit juice and the interaction may increase the effects of ixabepilone. You should discuss the use of grapefruit and grapefruit juice with your doctor.
rufinamide food
Applies to: rufinamide
Food can enhance the levels of rufinamide in your body. To ensure maximal oral absorption, rufinamide should be administered with or immediately after a meal. This will make it easier for your body to absorb the medication. Do not drink alcohol while you are taking rufinamide. Alcohol can increase some of the side effects including drowsiness or dizziness. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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