Drug Interactions between isoniazid and Triaminic Thin Strips Cough
This report displays the potential drug interactions for the following 2 drugs:
- isoniazid
- Triaminic Thin Strips Cough (dextromethorphan)
Interactions between your drugs
isoniazid dextromethorphan
Applies to: isoniazid and Triaminic Thin Strips Cough (dextromethorphan)
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration of isoniazid (INH), with drugs that possess serotonergic activity (e.g., serotonin reuptake inhibitors, 5-HT1 receptor agonists, ergot alkaloids, etc.) may increase the risk of serotonin syndrome, a rare but serious and potentially fatal condition. The proposed mechanism is an increase in serotonin resulting from INH's weak inhibition of monoamine oxidase (the enzyme primarily responsible for breaking down norepinephrine, serotonin, and dopamine) combined with the increase in serotonin from the serotonergic drug(s). In one case report, a patient taking mirtazapine (15 mg nightly) for depression was started on INH (300 mg daily) and pyridoxine (25 mg daily) for tuberculosis prophylaxis following a liver transplant from a donor with latent tuberculosis. Six days following the initiation of INH, the patient developed symptoms consistent with serotonin syndrome (e.g., diarrhea, nausea, tremors, hypertension, and altered mental status) which resolved upon the cessation of INH and mirtazapine. However, consensus on the safety of concomitant use of isoniazid with drugs possessing serotonergic activity is lacking and most of the existing data are limited to case reports.
MANAGEMENT: Until more information is available, coadministration of isoniazid with drugs that possess serotonergic activity (e.g., serotonin reuptake inhibitors, 5-HT1 receptor agonists, ergot alkaloids, etc.) should generally be avoided. If coadministration with a serotonergic drug is required, patients should be advised to promptly seek medical attention if they experience signs and symptoms of serotonin syndrome (including but not limited to confusion, hallucinations, tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, neuromuscular abnormalities and/or unexplained gastrointestinal symptoms).
References
- "Product Information. Isoniazid/Rifapentine 300 mg/300 mg (Macleods) (isoniazid-rifapentine)." Imported (India) 2 (2021):
- "Product Information. Isoniazid (isoniazid)." Chartwell RX, LLC. (2023):
- "Product Information. Isoniazid (Arrotex) (isoniazid)." Arrotex Pharmaceuticals Pty Ltd (2023):
- Stockley IH "Lack of clinical evidence for potential interaction between isoniazid and selective serotonin reuptake inhibitors https://academic.oup.com/ajhp/article-abstract/53/18/2217/5094445?redirectedFrom=fulltext" (2024):
- Evans ME, kortas kj "Potential interaction between isoniazid and selective serotonin reuptake inhibitors https://academic.oup.com/ajhp/article-abstract/52/19/2135/5094220?redirectedFrom=fulltext&login=false" (2024):
- "Product Information. Isoniazid (isoniazid)." RPH Pharmaceuticals AB (2023):
- OBrien M, Gandhi RG, Kotton CN, Adamsick ML "Risk of serotonin syndrome with Isoniazid https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927797/" (2024):
- "Product Information. Isotamine (isoniazid)." Bausch Health, Canada Inc. (2021):
Drug and food interactions
isoniazid food
Applies to: isoniazid
Food decreases the levels of isoniazid in your body. Take isoniazid on an empty stomach at least 1 hour before or 2 hours after a meal. This will make it easier for your body to absorb the medication. If nausea occurs, ask your doctor if you can take isoniazid with food. Avoid alcohol while taking isoniazid. Alcohol may increase the risk of damage to the liver during isoniazid treatment. Alcohol can also cause isoniazid side effects to get worse. Contact your doctor if you experience flushing, chills, headache, nausea, vomiting, and diarrhea.
dextromethorphan food
Applies to: Triaminic Thin Strips Cough (dextromethorphan)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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