Drug Interactions between Invega and lorcaserin

Using lorcaserin together with paliperidone may increase the risk of a rare but serious condition called the neuroleptic malignant syndrome, which may include symptoms such as agitation, confusion, delusion, hallucination, extreme changes in blood pressure, excessive sweating, fever, shivering or shaking, restlessness, muscle spasm or stiffness, tremor, and incoordination. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. In addition, both lorcaserin and paliperidone, especially when given long-term, can cause increases in the levels of a hormone called prolactin. The health effects of high levels of prolactin are not known; however, some patients (including men) have experienced increased breast size and milk or milky discharge from the breasts. Some breast cancers may also be dependent on prolactin; therefore, let your doctor know if you have a history of breast cancer. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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