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Drug Interactions between insulin degludec / liraglutide and methoxyflurane

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

methoxyflurane liraglutide

Applies to: methoxyflurane and insulin degludec / liraglutide

Medications like liraglutide can delay the emptying of food and liquid from your stomach. If you are scheduled for a surgery or procedure that requires general anesthesia with methoxyflurane, you may have residual contents in your stomach despite following the fasting instructions provided by your doctor. This can increase the risk of regurgitation during anesthesia and having the stomach contents inhaled into the lungs, which can cause inflammation or injury to the lungs, pneumonia, or even death. Therefore, it is important to let your doctor know prior to your surgery or procedure that you are receiving treatment with liraglutide. Depending on your condition and your individual circumstances, the doctor may instruct you to temporarily withhold treatment with liraglutide in advance, or they make take extra precaution during anesthesia and your surgery/procedure to minimize the risks. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interfere with the safety of your anesthesia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

liraglutide insulin degludec

Applies to: insulin degludec / liraglutide and insulin degludec / liraglutide

Using liraglutide together with insulin degludec can increase the risk of hypoglycemia, or low blood sugar. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Let your doctor know if you experience hypoglycemia during treatment. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

liraglutide food

Applies to: insulin degludec / liraglutide

Liraglutide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

insulin degludec food

Applies to: insulin degludec / liraglutide

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

methoxyflurane food

Applies to: methoxyflurane

Using methoxyflurane together with ethanol (alcohol) may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with methoxyflurane. Do not use more than the recommended dose of methoxyflurane, and avoid driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until you know how the medication affects you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.