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Drug Interactions between inotersen and NeoProfen

This report displays the potential drug interactions for the following 2 drugs:

  • inotersen
  • NeoProfen (ibuprofen)

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Interactions between your drugs

Major

ibuprofen inotersen

Applies to: NeoProfen (ibuprofen) and inotersen

Using inotersen together with ibuprofen may cause serious and potentially life-threatening bleeding complications. Treatment with inotersen can cause significant and sudden reductions in platelet count, which can lead to bleeding in some cases. The risk of bleeding may be further increased when combined with blood thinners or other medications that can also affect platelet count or function. In addition, inotersen may cause kidney problems including glomerulonephritis, which is an inflammatory condition of the kidney. Glomerulonephritis may result in kidney failure, and combining it with other medications that can also affect the kidney such as ibuprofen may increase that risk, especially if the latter is taken at high dosages or used chronically. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Also seek medical assistance if you develop signs and symptoms that may suggest glomerulonephritis such as puffiness or swelling in the face, hands, or feet; new onset or worsening shortness of breath or coughing; blood in the urine or brown urine; foamy urine (protein in the urine); and decreased urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No interactions were found. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.