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Drug Interactions between ifosfamide / mesna and Mycifradin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ifosfamide neomycin

Applies to: ifosfamide / mesna and Mycifradin (neomycin)

Using ifosfamide together with neomycin may increase the risk of kidney and/or nerve damage. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Be sure to drink plenty of fluids if you develop diarrhea or vomiting during treatment with these medications, as dehydration can also harm the kidney. In addition, let your doctor know if you develop seizures; hearing problems; or numbness, burning or tingling in your hands and feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

ifosfamide food

Applies to: ifosfamide / mesna

Do not consume grapefruit or grapefruit juice while you are receiving treatment with ifosfamide, as this may decrease the anticancer effects of ifosfamide and may increase its adverse effects on your nervous system and your kidneys. Do not use alcohol while you are receiving treatment with ifosfamide. This may increase nervous system side effects such as somnolence, dizziness, confusion, difficulty concentrating, and impairment of thinking and judgment; and may also increase nausea and vomiting. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Also, avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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