Drug Interactions between idelalisib and sofosbuvir / velpatasvir / voxilaprevir

Velpatasvir may increase the blood levels of idelalisib. This can increase the risk and/or severity of side effects such as liver problems, diarrhea, intestinal wall perforation, lung or breathing problems, and low white blood cell and platelet counts. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Also let your doctor know if the number of bowel movements per day increases by six or more, or if you experience other potentially serious side effects such as infection, coughing, difficulty breathing, and shortness of breath. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Voxilaprevir may increase the blood levels of idelalisib. This can increase the risk and/or severity of side effects such as liver problems, diarrhea, intestinal wall perforation, lung or breathing problems, and low white blood cell and platelet counts. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Also let your doctor know if the number of bowel movements per day increases by six or more, or if you experience other potentially serious side effects such as infection, coughing, difficulty breathing, and shortness of breath. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Velpatasvir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.