Drug Interactions between idelalisib and ribociclib

Idelalisib may cause serious and life-threatening liver problems, and using it with other medications that can also affect the liver such as ribociclib may increase that risk. Using ribociclib together with idelalisib may increase the blood levels of both medications. In addition to liver problems, this may increase the risk and/or severity of other side effects such as an irregular heart rhythm that may be serious and potentially life-threatening, low white blood cell and platelet counts, and infections. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Also let your doctor know if you experience other potentially serious side effects such as infection, coughing, difficulty breathing, sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment. Your doctor may want you to have ECGs performed regularly while you are on ribociclib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.