Can you take House dust mite allergen extract with RespiVent DF?
2 drug interactions and 42 additional warnings found for the following 2 drugs:
- house dust mite allergen extract
- RespiVent DF (chlorpheniramine/methscopolamine)
Drug interactions
Moderate drug interactions
Moderate:
chlorpheniramine methscopolamine
Applies to: RespiVent DF (chlorpheniramine / methscopolamine) and RespiVent DF (chlorpheniramine / methscopolamine)
Using chlorpheniramine together with methscopolamine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
chlorpheniramine house dust mite allergen extract
Applies to: RespiVent DF (chlorpheniramine / methscopolamine) and house dust mite allergen extract
Using house dust mite allergen extract together with chlorpheniramine may not be advisable. Immunotherapy with house dust mite allergen extract can sometimes cause severe, even potentially life-threatening allergic reactions that require emergency treatment with epinephrine, and medications like chlorpheniramine can potentiate the body's response to epinephrine and significantly increase its effects on blood pressure and heart rate as well as serious and potentially fatal irregular heart rhythms. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
chlorpheniramine Food/Lifestyle
Applies to: RespiVent DF (chlorpheniramine / methscopolamine)
Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with chlorpheniramine. Do not use more than the recommended dose of chlorpheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
house dust mite allergen extract Food/Lifestyle
Applies to: house dust mite allergen extract
Consuming food or beverage during or immediately after using house dust mite allergen extract may reduce the amount of allergen extract available for absorption from tissues under the tongue into the blood stream. Food or beverage should not be taken with, or for at least 5 minutes after, using house dust mite allergen extract. Use of alcohol with house dust mite allergen extract may increase the risk and severity of allergic reactions that can sometimes occur during treatment with house dust mite allergen extract. Potentially life-threatening or fatal reactions may occur. Talk to your doctor if you have any questions or concerns. Stop using house dust mite allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
methscopolamine Alcohol (Ethanol)
Applies to: RespiVent DF (chlorpheniramine / methscopolamine)
Ask your doctor before using methscopolamine together with ethanol (alcohol). Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking methscopolamine. You should be warned not to exceed recommended dosages and to avoid activities requiring mental alertness. If your doctor prescribes these medications together, you may need a dose adjustment to safely take this combination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
39 potential interactions Applies to: 29 conditions, including High Blood Pressure, GERD, Allergies, Asthma, and Heart Attack.
Allergies
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Allergies.
The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may cause severe allergic reactions such as anaphylaxis and laryngopharyngeal edema. These agents are contraindicated in patients with severe, unstable or uncontrolled asthma, a history of any severe systemic allergic reaction, and a history of any severe local reaction to sublingual allergen immunotherapy as these conditions could compromise breathing and be life-threatening.
Arrhythmia
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Arrhythmia.
Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Arrhythmia.
Anticholinergics block vagal inhibition of the SA nodal pacemaker. Therapy with anticholinergics should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with anticholinergics is rare.
Asthma
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Asthma.
The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may cause severe allergic reactions such as anaphylaxis and laryngopharyngeal edema. These agents are contraindicated in patients with severe, unstable or uncontrolled asthma, a history of any severe systemic allergic reaction, and a history of any severe local reaction to sublingual allergen immunotherapy as these conditions could compromise breathing and be life-threatening.
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Asthma.
The use of systemic anticholinergics is contraindicated in the treatment of lower respiratory tract symptoms including asthma. Muscarinic receptor antagonists reduce bronchial secretions, which can result in decreased fluidity and increased thickening of secretions. However, ipratropium does not produce these effects and can be used safely in treating asthma.
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Asthma.
It has been suggested that the anticholinergic effect of antihistamines may reduce the volume and cause thickening of bronchial secretions, resulting in obstruction of respiratory tract. Some manufacturers and clinicians recommend that therapy with antihistamines be administered cautiously in patients with asthma or chronic obstructive pulmonary disease.
Autoimmune Disorders
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Autoimmune Disorders.
The use of house dust mite allergen extract is contraindicated in patients with autoimmune disease due to the possibility of routine immunizations exacerbating symptoms of the underlying disease.
Autonomic Neuropathy
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Autonomic Neuropathy.
Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Therapy with antimuscarinic agents and higher dosages of antispasmodic agents (e.g., dicyclomine or oxybutynin) should be administered cautiously in patients with autonomic neuropathy.
Bleeding Disorder
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Bleeding Disorder.
The use of house dust mite allergen extract is contraindicated in patients with diseases characterized by a bleeding diathesis.
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Bleeding Disorder.
Antimuscarinic agents may cause a delay in gastric emptying and possibly antral stasis in patients with gastric ulcer. Therapy with antimuscarinic agents should be administered cautiously to patients with gastric ulcer.
Cardiovascular Conditions and Disorders
Moderate:
house dust mite allergen extract
House dust mite allergen extract has a moderate potential interaction with Cardiovascular Conditions and Disorders.
The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may not be suitable for patients with certain medical conditions that may reduce the ability to survive a serious allergic reaction or increase the risk of adverse reactions after epinephrine administration. Examples of these medical conditions include but are not limited to markedly compromised lung function (either chronic or acute), unstable angina, recent myocardial infarction, significant arrhythmia, and uncontrolled hypertension. It is recommended to exercise care in these patients.
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Cardiovascular Conditions and Disorders.
Antihistamines may infrequently cause cardiovascular adverse effects related to their anticholinergic and local anesthetic (quinidine-like) activities. Tachycardia, palpitation, ECG changes, arrhythmias, hypotension, and hypertension have been reported. Although these effects are uncommon and usually limited to overdosage situations, the manufacturers and some clinicians recommend that therapy with antihistamines be administered cautiously in patients with cardiovascular disease, hypertension, and/or hyperthyroidism.
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Cardiovascular Conditions and Disorders.
Anticholinergics block vagal inhibition of the SA nodal pacemaker. Therapy with anticholinergics should be administered cautiously to patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization, ventricular tachycardia, and fibrillation associated with anticholinergics are rare.
COPD
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with COPD.
It has been suggested that the anticholinergic effect of antihistamines may reduce the volume and cause thickening of bronchial secretions, resulting in obstruction of respiratory tract. Some manufacturers and clinicians recommend that therapy with antihistamines be administered cautiously in patients with asthma or chronic obstructive pulmonary disease.
Diarrhea
Minor:
RespiVent DF
The methscopolamine in RespiVent DF has a minor potential interaction with Diarrhea.
Diarrhea may be a symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Antimuscarinic agents may further aggravate the diarrhea. Therefore, these drugs should be administered cautiously in patients with diarrhea.
Esophageal Obstruction
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Esophageal Obstruction.
Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon.
Esophagitis
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Esophagitis.
The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts, is contraindicated in patients with a history of eosinophilic esophagitis. This condition could compromise swallowing, lead to food impaction, vomiting, and heartburn which may cause permanent damage to the esophagus.
Fever
Minor:
RespiVent DF
The methscopolamine in RespiVent DF has a minor potential interaction with Fever.
Atropine-like agents may increase the risk of hyperthermia in patients with fever by producing anhidrosis. Therapy with atropine-like agents should be administered cautiously in febrile patients.
Gastrointestinal Obstruction
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Gastrointestinal Obstruction.
Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Anticholinergics may further suppress intestinal motility with resultant precipitation or aggravation of toxic megacolon.
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Gastrointestinal Obstruction.
Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive. Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. In contrast, the newer, relatively nonsedating antihistamines (e.g., cetirizine, fexofenadine, loratadine) reportedly have low to minimal anticholinergic activity at normally recommended dosages and may be appropriate alternatives.
GERD
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with GERD.
Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. These drugs should be administered cautiously in patients with gastroesophageal reflux or hiatal hernia associated with reflux esophagitis.
Glaucoma/Intraocular Hypertension
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Glaucoma/Intraocular Hypertension.
Anticholinergic agents are contraindicated in patients with primary glaucoma, a tendency toward glaucoma (narrow anterior chamber angle), or adhesions (synechiae) between the iris and lens, as well as for the elderly and others in whom undiagnosed glaucoma or excessive pressure in the eye may be present. Because anticholinergics cause mydriasis, they may exacerbate these conditions.
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Glaucoma/Intraocular Hypertension.
Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive. Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. In contrast, the newer, relatively nonsedating antihistamines (e.g., cetirizine, fexofenadine, loratadine) reportedly have low to minimal anticholinergic activity at normally recommended dosages and may be appropriate alternatives.
Heart Attack
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Heart Attack.
The use of house dust mite allergen extract is contraindicated in patients who have experienced a recent myocardial infarction as these patients may not be able to tolerate immunotherapy. The benefit-to-risk ratio must be carefully evaluated before deciding to initiate such treatment.
Heart Disease
Moderate:
house dust mite allergen extract
House dust mite allergen extract has a moderate potential interaction with Heart Disease.
The use of allergen immunotherapy, such as mixed grass pollens, ragweed pollen, house dust mite allergen extract, and timothy grass pollen allergen extracts may not be suitable for patients with certain medical conditions that may reduce the ability to survive a serious allergic reaction or increase the risk of adverse reactions after epinephrine administration. Examples of these medical conditions include but are not limited to markedly compromised lung function (either chronic or acute), unstable angina, recent myocardial infarction, significant arrhythmia, and uncontrolled hypertension. It is recommended to exercise care in these patients.
High Blood Pressure
Minor:
RespiVent DF
The methscopolamine in RespiVent DF has a minor potential interaction with High Blood Pressure.
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
History - Myocardial Infarction
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with History - Myocardial Infarction.
The use of house dust mite allergen extract is contraindicated in patients who have experienced a recent myocardial infarction as these patients may not be able to tolerate immunotherapy. The benefit-to-risk ratio must be carefully evaluated before deciding to initiate such treatment.
Hyperthyroidism
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Hyperthyroidism.
Antihistamines may infrequently cause cardiovascular adverse effects related to their anticholinergic and local anesthetic (quinidine-like) activities. Tachycardia, palpitation, ECG changes, arrhythmias, hypotension, and hypertension have been reported. Although these effects are uncommon and usually limited to overdosage situations, the manufacturers and some clinicians recommend that therapy with antihistamines be administered cautiously in patients with cardiovascular disease, hypertension, and/or hyperthyroidism.
Minor:
RespiVent DF
The methscopolamine in RespiVent DF has a minor potential interaction with Hyperthyroidism.
In general, agents with anticholinergic activity may exacerbate hyperthyroidism. Therapy with anticholinergics should be administered cautiously in patients with hyperthyroidism. Thyroid levels should be monitored if usage is prolonged.
Hypotension
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Hypotension.
Antihistamines may infrequently cause cardiovascular adverse effects related to their anticholinergic and local anesthetic (quinidine-like) activities. Tachycardia, palpitation, ECG changes, arrhythmias, hypotension, and hypertension have been reported. Although these effects are uncommon and usually limited to overdosage situations, the manufacturers and some clinicians recommend that therapy with antihistamines be administered cautiously in patients with cardiovascular disease, hypertension, and/or hyperthyroidism.
Infectious Gastroenteritis
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Infectious Gastroenteritis.
The use of drugs with antiperistaltic activity (primarily antidiarrheal and antimuscarinic agents, but also antispasmodic agents such as dicyclomine or oxybutynin at high dosages) is contraindicated in patients with diarrhea due to pseudomembranous enterocolitis or enterotoxin-producing bacteria. These drugs may prolong and/or worsen diarrhea associated with organisms that invade the intestinal mucosa, such as toxigenic E. coli, Salmonella and Shigella, and pseudomembranous colitis due to broad-spectrum antibiotics. Other symptoms and complications such as fever, shedding of organisms and extraintestinal illness may also be increased or prolonged. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. Some cough and cold and other combination products may occasionally include antimuscarinic agents for their drying effects and may, therefore, require careful selection when necessary.
Ischemic Heart Disease
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Ischemic Heart Disease.
Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. These agents should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare.
Liver Disease
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Liver Disease.
Limited pharmacokinetic data are available for the older, first-generation antihistamines. Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients. Lower initial dosages may be appropriate.
Myasthenia Gravis
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Myasthenia Gravis.
Because antimuscarinic agents have anticholinergic effects, they are contraindicated in patients with myasthenia gravis. Their use may be appropriate to reduce adverse muscarinic effects caused by an anticholinesterase agent.
Nephrotic Syndrome
Major:
house dust mite allergen extract
House dust mite allergen extract has a major potential interaction with Nephrotic Syndrome.
The use of house dust mite allergen extract is contraindicated in children with nephrotic syndrome due to a variety of seemingly unrelated events that may cause an exacerbation of nephrotic disease.
Renal Dysfunction
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Renal Dysfunction.
Limited pharmacokinetic data are available for the older, first-generation antihistamines. Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients. Lower initial dosages may be appropriate.
Ulcerative Colitis
Moderate:
RespiVent DF
The methscopolamine in RespiVent DF has a moderate potential interaction with Ulcerative Colitis.
Antimuscarinic agents may suppress intestinal motility and produce paralytic ileus with resultant precipitation of toxic megacolon. These drugs should be administered cautiously to patients with ulcerative colitis.
Urinary Retention
Major:
RespiVent DF
The methscopolamine in RespiVent DF has a major potential interaction with Urinary Retention.
In general, the use of anticholinergic agents is contraindicated in patients with urinary retention and bladder neck obstruction caused by prostatic hypertrophy. Dysuria may occur and may require catheterization. Also, anticholinergic drugs may aggravate partial obstructive uropathy. Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients.
Moderate:
RespiVent DF
The chlorpheniramine in RespiVent DF has a moderate potential interaction with Urinary Retention.
Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive. Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. In contrast, the newer, relatively nonsedating antihistamines (e.g., cetirizine, fexofenadine, loratadine) reportedly have low to minimal anticholinergic activity at normally recommended dosages and may be appropriate alternatives.
More resources
house dust mite allergen extract
A total of 142 drugs are known to interact with house dust mite allergen extract.
- House dust mite allergen extract is in the drug class allergenics.
- House dust mite allergen extract is used to treat the following conditions:
RespiVent DF
A total of 412 drugs are known to interact with RespiVent DF.
- Respivent df is in the drug class upper respiratory combinations.
- Respivent df is used to treat Rhinitis.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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