Drug Interactions between Hepzato and tocilizumab

Using tocilizumab together with melphalan may increase the risk of serious infections. In addition, tocilizumab may decrease the blood levels and effects of melphalan. You may need a dose adjustment if you have been receiving melphalan and are starting treatment with tocilizumab. Likewise, if you have been receiving both medications, the dose of melphalan may need to be adjusted if tocilizumab is discontinued. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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