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Drug Interactions between glycerol phenylbutyrate and Proben-C

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

probenecid glycerol phenylbutyrate

Applies to: Proben-C (colchicine / probenecid) and glycerol phenylbutyrate

Talk to your doctor before using probenecid together with glycerol phenylbutyrate. Probenecid may interfere with the excretion of metabolites of glycerol phenylbutyrate into the urine. Since blood and urine levels of these metabolites may be used to help guide glycerol phenylbutyrate treatment and determine effectiveness, your doctor will need to be aware of this interaction when making any dose adjustments. In addition, you may be at increased risk of developing nervous system side effects associated with one of the metabolites, including drowsiness, lightheadedness, fatigue, headache, taste disturbances, hearing problems, confusion, memory impairment, tremor, and seizures. You should contact your doctor immediately if you experience these or other unusual symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

colchicine food

Applies to: Proben-C (colchicine / probenecid)

Drinking large amounts of grapefruit juice can increase your blood levels of colchicine to dangerous levels. You should avoid the consumption of grapefruit or grapefruit juice during treatment with colchicine. Let your doctor know if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet, as these may be early symptoms of colchicine toxicity.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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