Skip to main content

Drug Interactions between glasdegib and tecovirimat

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

glasdegib tecovirimat

Applies to: glasdegib and tecovirimat

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of glasdegib, which is primarily metabolized by the isoenzyme and to a lesser extent CYP450 2C8 and UGT1A9. When glasdegib was coadministered with rifampin, a potent CYP450 3A4 inducer, glasdegib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 35% and 70%, respectively, compared to administration of glasdegib alone. Coadministration with efavirenz, a moderate CYP450 3A4 inducer, is predicted to decrease glasdegib Cmax and AUC by 25% and 55%, respectively. Reduced efficacy of glasdegib may occur. The interaction has not been studied with other, less potent inducers.

MANAGEMENT: The potential for diminished pharmacologic effects of glasdegib should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.

References

  1. "Product Information. Daurismo (glasdegib)." Pfizer U.S. Pharmaceuticals Group (2023):
  2. "Product Information. Daurismo (glasdegib)." Pfizer Ltd (2022):
  3. "Product Information. Daurismo (glasdegib)." Pfizer Canada ULC (2022):

Drug and food interactions

Moderate

glasdegib food

Applies to: glasdegib

Grapefruit and grapefruit juice may increase the blood levels and effects of glasdegib. This can increase the risk of serious side effects such as an irregular heart rhythm, inflammation and ulceration of the digestive tract, low red or white blood cells, fever, low platelet levels, bleeding, and swelling. You should avoid consumption of grapefruit and grapefruit juice during treatment with glasdegib. Otherwise, you may need a dose adjustment and/or more frequent monitoring by your doctor to safely use this medication. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

tecovirimat food

Applies to: tecovirimat

Food may increase the absorption of tecovirimat when taken orally, which may lead to higher blood levels of the medication. You should take oral preparations of tecovirimat within 30 minutes after a full meal containing moderate or high fat (approximately 600 calories and 25 g of fat) with 6 to 8 ounces of water.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer